Cytosolic DNA sensors in neurodegenerative diseases: from physiological defenders to pathological culprits

Cytosolic DNA sensors in neurodegenerative diseases: from physiological defenders to pathological culprits

Abstract Cytosolic DNA sensors are a group of pattern recognition receptors (PRRs) that vary in structures, molecular mechanisms, and origins but share a common function to detect intracellular microbial DNA and trigger the innate immune response like type 1 interferon production and autophagy. Cyto...

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Bibliographic Details
Main Authors: Jiatian Xie, Jinping Cheng, Ho Ko, Yamei Tang
Format: Article
Language:English
Published: Springer Nature 2024-03-01
Series:EMBO Molecular Medicine
Subjects:
Cytosolic DNA
Neurodegeneration
STING
Innate Immune
Type 1 Interferon
Online Access:https://doi.org/10.1038/s44321-024-00046-w

Internet

https://doi.org/10.1038/s44321-024-00046-w

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