A Naturally Derived Watercress Flower-Based Phenethyl Isothiocyanate-Enriched Extract Induces the Activation of Intrinsic Apoptosis via Subcellular Ultrastructural and Ca<sup>2+</sup> Efflux Alterations in an In Vitro Model of Human Malignant Melanoma

A Naturally Derived Watercress Flower-Based Phenethyl Isothiocyanate-Enriched Extract Induces the Activation of Intrinsic Apoptosis via Subcellular Ultrastructural and Ca<sup>2+</sup> Efflux Alterations in an In Vitro Model of Human Malignant Melanoma

The aim of the current study was to (i) extract isolated fractions of watercress flowers enriched in polyphenols, phenethyl isothiocyanate and glucosinolates and (ii) characterize the anticancer mode of action of non-lethal, sub-lethal and lethal concentrations of the most potent extract fraction in...

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Bibliographic Details
Main Authors: Sotiris Kyriakou, Louiza Potamiti, Nikoletta Demosthenous, Tom Amery, Kyle Stewart, Paul G. Winyard, Rodrigo Franco, Aglaia Pappa, Mihalis I. Panayiotidis
Format: Article
Language:English
Published: MDPI AG 2023-09-01
Series:Nutrients
Subjects:
watercress
phenethyl isothiocyanate
mitochondria
endoplasmic reticulum
calcium efflux
apoptosis
Online Access:https://www.mdpi.com/2072-6643/15/18/4044

Internet

https://www.mdpi.com/2072-6643/15/18/4044

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