Structure‐Based Discovery of A Small Molecule Inhibitor of Histone Deacetylase 6 (HDAC6) that Significantly Reduces Alzheimer's Disease Neuropathology

Structure‐Based Discovery of A Small Molecule Inhibitor of Histone Deacetylase 6 (HDAC6) that Significantly Reduces Alzheimer's Disease Neuropathology

Abstract Histone deacetylase 6 (HDAC6) is one of the key histone deacetylases (HDACs) that regulates various cellular functions including clearance of misfolded protein and immunological responses. Considerable evidence suggests that HDAC6 is closely related to amyloid and tau pathology, the two pri...

Full description

Bibliographic Details
Main Authors: Prasenjit Mondal, Ping Bai, Ashley Gomm, Grisilda Bakiasi, Chih‐Chung Jerry Lin, Yanli Wang, Se Hoon Choi, Rudolph E. Tanzi, Changning Wang, Can Zhang
Format: Article
Language:English
Published: Wiley 2024-01-01
Series:Advanced Science
Subjects:
acetylation
Alzheimer's disease
epigenetic
HDAC6 inhibitor
neuroinflammation
phagocytosis
Online Access:https://doi.org/10.1002/advs.202304545

Internet

https://doi.org/10.1002/advs.202304545

Similar Items