Skeletal FGFR1 signaling is necessary for regulation of serum phosphate level by FGF23 and normal life span

Skeletal FGFR1 signaling is necessary for regulation of serum phosphate level by FGF23 and normal life span

Fibroblast growth factor (FGF) 23 produced by the bone is the principal hormone to regulate serum phosphate level. Serum FGF23 needs to be tightly regulated to maintain serum phosphate in a narrow range. Thus, we hypothesized that the bone has some phosphate-sensing mechanism to regulate the product...

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Bibliographic Details
Main Authors: Yuichi Takashi, Shun Sawatsubashi, Itsuro Endo, Yukiyo Ohnishi, Masahiro Abe, Munehide Matsuhisa, Daiji Kawanami, Toshio Matsumoto, Seiji Fukumoto
Format: Article
Language:English
Published: Elsevier 2021-09-01
Series:Biochemistry and Biophysics Reports
Subjects:
Phosphate
Fibroblast growth factor 23
Fibroblast growth factor receptor 1
Life span
Online Access:http://www.sciencedirect.com/science/article/pii/S2405580821002028

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http://www.sciencedirect.com/science/article/pii/S2405580821002028

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