Program Cell Death Receptor-1-Mediated Invariant Natural Killer T-Cell Control of Peritoneal Macrophage Modulates Survival in Neonatal Sepsis

Program Cell Death Receptor-1-Mediated Invariant Natural Killer T-Cell Control of Peritoneal Macrophage Modulates Survival in Neonatal Sepsis

We have shown that invariant natural killer T (iNKT) cells mediate sepsis-induced end-organ changes and immune responses, including macrophage bacterial phagocytosis, a finding regulated by the check point protein program cell death receptor-1 (PD-1). Furthermore, PD-1 mediates mortality in both adu...

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Bibliographic Details
Main Authors: Eleanor A. Fallon, Tristen T. Chun, Whitney A. Young, Chyna Gray, Alfred Ayala, Daithi S. Heffernan
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-11-01
Series:Frontiers in Immunology
Subjects:
invariant natural killer T cells
programmed cell death receptor-1
neonatal
sepsis
peritoneal macrophage
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.01469/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.01469/full

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