A potent bispecific nanobody protects hACE2 mice against SARS-CoV-2 infection via intranasal administration

A potent bispecific nanobody protects hACE2 mice against SARS-CoV-2 infection via intranasal administration

Summary: The dramatically expanding coronavirus disease 2019 (COVID-19) needs multiple effective countermeasures. Neutralizing nanobodies (Nbs) are a potential therapeutic strategy for treating COVID-19. Here, we characterize several receptor binding domain (RBD)-specific Nbs isolated from an Nb lib...

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Bibliographic Details
Main Authors: Xilin Wu, Lin Cheng, Ming Fu, Bilian Huang, Linjing Zhu, Shijie Xu, Haixia Shi, Doudou Zhang, Huanyun Yuan, Waqas Nawaz, Ping Yang, Qinxue Hu, Yalan Liu, Zhiwei Wu
Format: Article
Language:English
Published: Elsevier 2021-10-01
Series:Cell Reports
Subjects:
SARS-CoV-2
nanobody
intranasal
Nb15
bispecific
hACE2 mice
Online Access:http://www.sciencedirect.com/science/article/pii/S221112472101336X

Internet

http://www.sciencedirect.com/science/article/pii/S221112472101336X

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