Femtomolar and locus-specific detection of N6-methyladenine in DNA by integrating double-hindered replication and nucleic acid-functionalized MB@Zr-MOF

Femtomolar and locus-specific detection of N6-methyladenine in DNA by integrating double-hindered replication and nucleic acid-functionalized MB@Zr-MOF

Abstract In this study, a novel electrochemical biosensor was constructed for ultrasensitive and locus-specific detection of N6-Methyladenine (m6A) in DNA using double-hindered replication and nucleic acid-coated methylene blue (MB)@Zr-MOF. Based on the combination of m6A-impeded replication and AgI...

Full description

Bibliographic Details
Main Authors: Qingyuan Zheng, Tong Wang, Xinmin Li, Husun Qian, Xintong Bian, Xingrong Li, Huijie Bai, Shijia Ding, Yurong Yan
Format: Article
Language:English
Published: BMC 2021-12-01
Series:Journal of Nanobiotechnology
Subjects:
N6-Methyladenine DNA
Double-hindered replication
MOF
Electrochemical biosensor
Online Access:https://doi.org/10.1186/s12951-021-01156-0

Internet

https://doi.org/10.1186/s12951-021-01156-0

Similar Items