Femtomolar and locus-specific detection of N6-methyladenine in DNA by integrating double-hindered replication and nucleic acid-functionalized MB@Zr-MOF
Abstract In this study, a novel electrochemical biosensor was constructed for ultrasensitive and locus-specific detection of N6-Methyladenine (m6A) in DNA using double-hindered replication and nucleic acid-coated methylene blue (MB)@Zr-MOF. Based on the combination of m6A-impeded replication and AgI...
Main Authors: | Qingyuan Zheng, Tong Wang, Xinmin Li, Husun Qian, Xintong Bian, Xingrong Li, Huijie Bai, Shijia Ding, Yurong Yan |
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Format: | Article |
Language: | English |
Published: |
BMC
2021-12-01
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Series: | Journal of Nanobiotechnology |
Subjects: | |
Online Access: | https://doi.org/10.1186/s12951-021-01156-0 |
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