Antibody elicited by HIV-1 immunogen vaccination in macaques displaces Env fusion peptide and destroys a neutralizing epitope

Antibody elicited by HIV-1 immunogen vaccination in macaques displaces Env fusion peptide and destroys a neutralizing epitope

Abstract HIV-1 vaccine design aims to develop an immunogen that elicits broadly neutralizing antibodies against a desired epitope, while eliminating responses to off-target regions of HIV-1 Env. We report characterization of Ab1245, an off-target antibody against the Env gp120-gp41 interface, from V...

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Bibliographic Details
Main Authors: Morgan E. Abernathy, Harry B. Gristick, Jost Vielmetter, Jennifer R. Keeffe, Priyanthi N. P. Gnanapragasam, Yu E. Lee, Amelia Escolano, Rajeev Gautam, Michael S. Seaman, Malcolm A. Martin, Michel C. Nussenzweig, Pamela J. Bjorkman
Format: Article
Language:English
Published: Nature Portfolio 2021-10-01
Series:npj Vaccines
Online Access:https://doi.org/10.1038/s41541-021-00387-4

Internet

https://doi.org/10.1038/s41541-021-00387-4

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