Enhanced Transdermal Delivery of Bisoprolol Hemifumarate via Combined Effect of Iontophoresis and Chemical Enhancers: Ex Vivo Permeation/In Vivo Pharmacokinetic Studies

Enhanced Transdermal Delivery of Bisoprolol Hemifumarate via Combined Effect of Iontophoresis and Chemical Enhancers: Ex Vivo Permeation/In Vivo Pharmacokinetic Studies

Bisoprolol hemifumarate (BH) is an antihypertensive drug that is used as first-line treatment for chronic hypertension and angina pectoris. Our study was performed to enhance the transdermal delivery of BH, a hydrophilic drug active with high molecular weight, through differently prepared hydrogels....

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Bibliographic Details
Main Authors: Mahmoud H. Teaima, Mohamed Azmi Ahmed Mohamed, Randa Tag Abd El Rehem, Saadia A. Tayel, Mohamed A. El-Nabarawi, Shahinaze A. Fouad
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Pharmaceutics
Subjects:
bisoprolol hemifumarate (BH)
hypertension
hydrogels
ex vivo permeation
permeation enhancers
rat skin
Online Access:https://www.mdpi.com/1999-4923/13/5/682

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https://www.mdpi.com/1999-4923/13/5/682

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