Pioglitazone strengthen therapeutic effect of adipose-derived regenerative cells against ischemic cardiomyopathy through enhanced expression of adiponectin and modulation of macrophage phenotype

Pioglitazone strengthen therapeutic effect of adipose-derived regenerative cells against ischemic cardiomyopathy through enhanced expression of adiponectin and modulation of macrophage phenotype

Abstract Background The efficacy of cell transplantation in heart failure is reportedly modest, but adjuvant drugs combined with cell therapy may improve this efficacy. Peroxisome proliferator-activated receptor (PPAR)γ, one of the hypoglycemic medicine for diabetes mellitus, reportedly enhances cyt...

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Bibliographic Details
Main Authors: Daisuke Mori, Shigeru Miyagawa, Ryohei Matsuura, Nagako Sougawa, Satsuki Fukushima, Takayoshi Ueno, Koichi Toda, Toru Kuratani, Koichi Tomita, Norikazu Maeda, Iichiro Shimomura, Yoshiki Sawa
Format: Article
Language:English
Published: BMC 2019-03-01
Series:Cardiovascular Diabetology
Subjects:
Adipose-derived regenerative cells
Ischemic cardiomyopathy
Adiponectin
T-cadherin
Macrophage
Online Access:http://link.springer.com/article/10.1186/s12933-019-0829-x

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http://link.springer.com/article/10.1186/s12933-019-0829-x

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