Identification of a distal enhancer regulating hedgehog interacting protein gene in human lung epithelial cellsResearch in context

Identification of a distal enhancer regulating hedgehog interacting protein gene in human lung epithelial cellsResearch in context

Summary: Background: An intergenic region at chromosome 4q31 is one of the most significant regions associated with COPD susceptibility and lung function in GWAS. In this region, the implicated causal gene HHIP has a unique epithelial expression pattern in adult human lungs, in contrast to dominant...

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Main Authors: Feng Guo, Li Zhang, Yuzhen Yu, Lu Gong, Shiyue Tao, Rhiannon B. Werder, Shreya Mishra, Yihan Zhou, Wardatul Jannat Anamika, Taotao Lao, Hiroyuki Inuzuka, Yihan Zhang, Betty Pham, Tao Liu, Tiffany S. Tufenkjian, Bradley W. Richmond, Wenyi Wei, Hongmei Mou, Andrew A. Wilson, Ming Hu, Wei Chen, Xiaobo Zhou
Format: Article
Language:English
Published: Elsevier 2024-03-01
Series:EBioMedicine
Subjects:
Chronic obstructive pulmonary disease
Distal enhancer
Hi-C
Epithelial-mesenchymal transition
TGFβ
Epigenetics
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396424000616

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http://www.sciencedirect.com/science/article/pii/S2352396424000616

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