PGM3 inhibition shows cooperative effects with erastin inducing pancreatic cancer cell death via activation of the unfolded protein response

PGM3 inhibition shows cooperative effects with erastin inducing pancreatic cancer cell death via activation of the unfolded protein response

BackgroundPancreatic ductal adenocarcinoma (PDAC) is a highly aggressive cancer with a poor patient prognosis. Remarkably, PDAC is one of the most aggressive and deadly tumor types and is notorious for its resistance to all types of treatment. PDAC resistance is frequently associated with a wide met...

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Bibliographic Details
Main Authors: Barbara Zerbato, Maximilian Gobbi, Tobias Ludwig, Virginia Brancato, Alex Pessina, Luca Brambilla, Andre Wegner, Ferdinando Chiaradonna
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-05-01
Series:Frontiers in Oncology
Subjects:
hexosamine biosynthetic pathway
unfolded protein response
pancreatic cancer cells
cell death
erastin
ferroptosis
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2023.1125855/full

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https://www.frontiersin.org/articles/10.3389/fonc.2023.1125855/full

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