Virus-Intrinsic Differences and Heterogeneous IRF3 Activation Influence IFN-Independent Antiviral Protection

Virus-Intrinsic Differences and Heterogeneous IRF3 Activation Influence IFN-Independent Antiviral Protection

Summary: Type 1 interferon (IFN) plays a critical role in early antiviral defense and priming of adaptive immunity by signaling upregulation of host antiviral IFN-stimulated genes (ISGs). Certain stimuli trigger strong activation of IFN regulatory factor 3 (IRF3) and direct upregulation of ISGs in a...

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Bibliographic Details
Main Authors: David N. Hare, Kaushal Baid, Anna Dvorkin-Gheva, Karen L. Mossman
Format: Article
Language:English
Published: Elsevier 2020-12-01
Series:iScience
Subjects:
Biological Sciences
Molecular Biology
Microbiology
Virology
Cell Biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004220310610

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http://www.sciencedirect.com/science/article/pii/S2589004220310610

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