High-throughput screening of inhibitors of NMNAT1 and their tumor-targeting functions

High-throughput screening of inhibitors of NMNAT1 and their tumor-targeting functions

Objective To find new drug candidates for cancer treatment by screening inhibitors of NMNAT1 using recombinant human NMNAT1 expressed in E. coli system. Methods The human NMNAT1 was inserted into the pET21b(+) vector and the recombinant plasmid was transformed into E. coli BL21(DE3) strain for over...

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Bibliographic Details
Main Author: SHA Wu-ga, LI Jun
Format: Article
Language:zho
Published: Institute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College. 2022-06-01
Series:Jichu yixue yu linchuang
Subjects:
nicotinamide single nucleotide adenosine transferase 1(nmnat1)|protein purification|high-throughput chemical screening|apoptosis
Online Access:http://journal11.magtechjournal.com/Jwk_jcyxylc/fileup/1001-6325/PDF/1001-6325-2022-42-6-933.pdf

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http://journal11.magtechjournal.com/Jwk_jcyxylc/fileup/1001-6325/PDF/1001-6325-2022-42-6-933.pdf

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