Multiple Targets of 3-Dehydroxyceanothetric Acid 2-Methyl Ester to Protect Against Cisplatin-Induced Cytotoxicity in Kidney Epithelial LLC-PK1 Cells

Multiple Targets of 3-Dehydroxyceanothetric Acid 2-Methyl Ester to Protect Against Cisplatin-Induced Cytotoxicity in Kidney Epithelial LLC-PK1 Cells

Chronic exposure to cisplatin, a potent anticancer drug, causes irreversible kidney damage. In this study, we investigated the protective effect and mechanism of nine lupane- and ceanothane-type triterpenoids isolated from jujube (Ziziphus jujuba Mill., Rhamnaceae) on cisplatin-induced damage to kid...

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Bibliographic Details
Main Authors: Dahae Lee, Ki Hyun Kim, Won Yung Lee, Chang-Eop Kim, Sang Hyun Sung, Kyo Bin Kang, Ki Sung Kang
Format: Article
Language:English
Published: MDPI AG 2019-03-01
Series:Molecules
Subjects:
cisplatin
MAPKs
nephrotoxicity
apoptosis
Online Access:http://www.mdpi.com/1420-3049/24/5/878

Internet

http://www.mdpi.com/1420-3049/24/5/878

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