Ecological effects of stress drive bacterial evolvability under sub-inhibitory antibiotic treatments

Abstract Stress is thought to increase mutation rate and thus to accelerate evolution. In the context of antibiotic resistance, sub-inhibitory treatments could then lead to enhanced evolvability, thereby fuelling the adaptation of pathogens. Combining wet-lab experiments, stochastic simulations and...

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Bibliographic Details
Main Authors: Marie Vasse, Sebastian Bonhoeffer, Antoine Frenoy
Format: Article
Language:English
Published: Oxford University Press 2022-09-01
Series:ISME Communications
Online Access:https://doi.org/10.1038/s43705-022-00157-w