Analysis of hereditary cancer syndromes by using a panel of genes: novel and multiple pathogenic mutations

Analysis of hereditary cancer syndromes by using a panel of genes: novel and multiple pathogenic mutations

Abstract Background Hereditary cancer predisposition syndromes are responsible for approximately 5–10% of all diagnosed cancer cases. In the past, single-gene analysis of specific high risk genes was used for the determination of the genetic cause of cancer heritability in certain families. The appl...

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Main Authors: Georgios N. Tsaousis, Eirini Papadopoulou, Angela Apessos, Konstantinos Agiannitopoulos, Georgia Pepe, Stavroula Kampouri, Nikolaos Diamantopoulos, Theofanis Floros, Rodoniki Iosifidou, Ourania Katopodi, Anna Koumarianou, Christos Markopoulos, Konstantinos Papazisis, Vasileios Venizelos, Ioannis Xanthakis, Grigorios Xepapadakis, Eugeniu Banu, Dan Tudor Eniu, Serban Negru, Dana Lucia Stanculeanu, Andrei Ungureanu, Vahit Ozmen, Sualp Tansan, Mehmet Tekinel, Suayib Yalcin, George Nasioulas
Format: Article
Language:English
Published: BMC 2019-06-01
Series:BMC Cancer
Subjects:
Next generation sequencing
Cancer susceptibility genes
Breast cancer
Hereditary cancer
BRCA1 & BRCA2
Multigene panels
Online Access:http://link.springer.com/article/10.1186/s12885-019-5756-4

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http://link.springer.com/article/10.1186/s12885-019-5756-4

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