Immune Escape via a Transient Gene Expression Program Enables Productive Replication of a Latent Pathogen

Immune Escape via a Transient Gene Expression Program Enables Productive Replication of a Latent Pathogen

How type I and II interferons prevent periodic reemergence of latent pathogens in tissues of diverse cell types remains unknown. Using homogeneous neuron cultures latently infected with herpes simplex virus 1, we show that extrinsic type I or II interferon acts directly on neurons to induce unique g...

Full description

Bibliographic Details
Main Authors: Jessica A. Linderman, Mariko Kobayashi, Vinayak Rayannavar, John J. Fak, Robert B. Darnell, Moses V. Chao, Angus C. Wilson, Ian Mohr
Format: Article
Language:English
Published: Elsevier 2017-01-01
Series:Cell Reports
Subjects:
interferon
latency
reactivation
herpesvirus
gene expression
neurons
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717300499

Internet

http://www.sciencedirect.com/science/article/pii/S2211124717300499

Similar Items