Comprehensive Analysis of the Genetic and Epigenetic Mechanisms of Osteoporosis and Bone Mineral Density

Comprehensive Analysis of the Genetic and Epigenetic Mechanisms of Osteoporosis and Bone Mineral Density

Osteoporosis is a skeletal disorder characterized by a systemic impairment of bone mineral density (BMD). Genome-wide association studies (GWAS) have identified hundreds of susceptibility loci for osteoporosis and BMD. However, the vast majority of susceptibility loci are located in non-coding regio...

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Bibliographic Details
Main Authors: Hui Dong, Wenyang Zhou, Pingping Wang, Enjun Zuo, Xiaoxia Ying, Songling Chai, Tao Fei, Laidi Jin, Chen Chen, Guowu Ma, Huiying Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-03-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
genome-wide association study
osteoporosis
bone mineral density
summary data-based Mendelian randomization
functional element enrichment analysis
Online Access:https://www.frontiersin.org/article/10.3389/fcell.2020.00194/full

Internet

https://www.frontiersin.org/article/10.3389/fcell.2020.00194/full

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