Nicotinamide activates latent HIV-1 ex vivo in ART suppressed individuals, revealing higher potency than the association of two methyltransferase inhibitors, chaetocin and BIX01294

Nicotinamide activates latent HIV-1 ex vivo in ART suppressed individuals, revealing higher potency than the association of two methyltransferase inhibitors, chaetocin and BIX01294

Background: Latent HIV-1 is a major hurdle in obtaining HIV-1 sustained virological remission (SVR). Here we explored histone deacetylation inhibition property of nicotinamide (NAM; n = 17) for the first time in comparison to a combination of methyltransferase inhibitors (MTIs; Chaetocin and BIX0129...

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Bibliographic Details
Main Authors: Sadia Samer, Muhammad Shoaib Arif, Leila Bertoni Giron, Jean Paulo Lopes Zukurov, James Hunter, Bruna Teresa Santillo, Gislene Namiyama, Juliana Galinskas, Shirley Vasconcelos Komninakis, Telma Miyuki Oshiro, Maria Cecilia Sucupira, Luiz Mario Janini, Ricardo Sobhie Diaz
Format: Article
Language:English
Published: Elsevier 2020-03-01
Series:Brazilian Journal of Infectious Diseases
Subjects:
Nicotinamide
Latency reversal agents
Histone deacetylases inhibitor
Methyltransferase inhibitors
Chaetocin
BIX01294
Online Access:http://www.sciencedirect.com/science/article/pii/S1413867020300192

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http://www.sciencedirect.com/science/article/pii/S1413867020300192

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