Desmoglein 2 regulates cardiogenesis by restricting hematopoiesis in the developing murine heart

Abstract Cardiac morphogenesis relies on intricate intercellular signaling. Altered signaling impacts cardiac function and is detrimental to embryonic survival. Here we report an unexpected regulatory role of the desmosomal cell adhesion molecule desmoglein 2 (Dsg2) on murine heart development. A la...

Full description

Bibliographic Details
Main Authors: Hoda Moazzen, Kateryna Venger, Sebastian Kant, Rudolf E. Leube, Claudia A. Krusche
Format: Article
Language:English
Published: Nature Portfolio 2021-11-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-00996-y