MR Imaging and Electrophysiological Features of Doxorubicin-Induced Fibrosis: Protocol Development in a Small Preclinical Pig Study with Histological Validation

MR Imaging and Electrophysiological Features of Doxorubicin-Induced Fibrosis: Protocol Development in a Small Preclinical Pig Study with Histological Validation

A critical chemotherapeutic complication is cardiotoxicity, often leading, in time, to heart failure. In this work, we developed a novel animal protocol using magnetic resonance (MR) imaging and electrophysiology (EP) tests, designed to detect subtle structural and functional changes associated with...

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Bibliographic Details
Main Authors: Peter Lin, Terenz Escartin, Melissa Larsen, Matthew Ng, Mengyuan Li, Jennifer Barry, Idan Roifman, Mihaela Pop
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:Applied Sciences
Subjects:
cardiotoxicity
MRI
fibrosis
chemotherapy
doxorubicin
voltage mapping
Online Access:https://www.mdpi.com/2076-3417/12/22/11620

Internet

https://www.mdpi.com/2076-3417/12/22/11620

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