Mitochondrial Trafficking and Processing of Telomerase RNA TERC

Summary: Mitochondrial dysfunctions play major roles in many diseases. However, how mitochondrial stresses are relayed to downstream responses remains unclear. Here we show that the RNA component of mammalian telomerase TERC is imported into mitochondria, processed to a shorter form TERC-53, and the...

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Bibliographic Details
Main Authors: Ying Cheng, Peipei Liu, Qian Zheng, Ge Gao, Jiapei Yuan, Pengfeng Wang, Jinliang Huang, Leiming Xie, Xinping Lu, Tanjun Tong, Jun Chen, Zhi Lu, Jisong Guan, Geng Wang
Format: Article
Language:English
Published: Elsevier 2018-09-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124718312440