Mitochondrial Trafficking and Processing of Telomerase RNA TERC
Summary: Mitochondrial dysfunctions play major roles in many diseases. However, how mitochondrial stresses are relayed to downstream responses remains unclear. Here we show that the RNA component of mammalian telomerase TERC is imported into mitochondria, processed to a shorter form TERC-53, and the...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2018-09-01
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| Series: | Cell Reports |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124718312440 |
| _version_ | 1819106309917638656 |
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| author | Ying Cheng Peipei Liu Qian Zheng Ge Gao Jiapei Yuan Pengfeng Wang Jinliang Huang Leiming Xie Xinping Lu Tanjun Tong Jun Chen Zhi Lu Jisong Guan Geng Wang |
| author_facet | Ying Cheng Peipei Liu Qian Zheng Ge Gao Jiapei Yuan Pengfeng Wang Jinliang Huang Leiming Xie Xinping Lu Tanjun Tong Jun Chen Zhi Lu Jisong Guan Geng Wang |
| author_sort | Ying Cheng |
| collection | DOAJ |
| description | Summary: Mitochondrial dysfunctions play major roles in many diseases. However, how mitochondrial stresses are relayed to downstream responses remains unclear. Here we show that the RNA component of mammalian telomerase TERC is imported into mitochondria, processed to a shorter form TERC-53, and then exported back to the cytosol. We found that the import is regulated by PNPASE, and the processing is controlled by mitochondrion-localized RNASET2. Cytosolic TERC-53 levels respond to changes in mitochondrial functions but have no direct effect on these functions. These findings uncover a mitochondrial RNA trafficking pathway and provide a potential mechanism for mitochondria to relay their functional states to other cellular compartments. : The functions of most mitochondrial RNAs imported from the cytosol are poorly understood. Cheng et al. provide evidence that the RNA component of mammalian telomerase TERC is imported into mitochondria, processed to a shorter form TERC-53, and then exported back to the cytosol. The cytosolic TERC-53 level serves as a potential indicator of mitochondrial functions. Keywords: mitochondria, RNA, import, export, processing, mitochondrial dysfunction, retrograde signaling, TERC, telomerase, RNASET2 |
| first_indexed | 2024-12-22T02:36:06Z |
| format | Article |
| id | doaj.art-dc5551f14d7c4a0b93243338ba3f4f53 |
| institution | Directory Open Access Journal |
| issn | 2211-1247 |
| language | English |
| last_indexed | 2024-12-22T02:36:06Z |
| publishDate | 2018-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cell Reports |
| spelling | doaj.art-dc5551f14d7c4a0b93243338ba3f4f532022-12-21T18:41:45ZengElsevierCell Reports2211-12472018-09-01241025892595Mitochondrial Trafficking and Processing of Telomerase RNA TERCYing Cheng0Peipei Liu1Qian Zheng2Ge Gao3Jiapei Yuan4Pengfeng Wang5Jinliang Huang6Leiming Xie7Xinping Lu8Tanjun Tong9Jun Chen10Zhi Lu11Jisong Guan12Geng Wang13MOE Key Laboratory of Bioinformatics, Cell Biology and Development Center, School of Life Sciences, Tsinghua University, Beijing 100084, ChinaMOE Key Laboratory of Bioinformatics, Cell Biology and Development Center, School of Life Sciences, Tsinghua University, Beijing 100084, ChinaMOE Key Laboratory of Bioinformatics, Cell Biology and Development Center, School of Life Sciences, Tsinghua University, Beijing 100084, ChinaMOE Key Laboratory of Bioinformatics, Cell Biology and Development Center, School of Life Sciences, Tsinghua University, Beijing 100084, ChinaMOE Key Laboratory of Bioinformatics, Cell Biology and Development Center, School of Life Sciences, Tsinghua University, Beijing 100084, ChinaPeking University Research Center on Aging, Beijing 100191, ChinaMOE Key Laboratory of Bioinformatics, Cell Biology and Development Center, School of Life Sciences, Tsinghua University, Beijing 100084, ChinaMOE Key Laboratory of Bioinformatics, Cell Biology and Development Center, School of Life Sciences, Tsinghua University, Beijing 100084, ChinaMOE Key Laboratory of Bioinformatics, Cell Biology and Development Center, School of Life Sciences, Tsinghua University, Beijing 100084, ChinaPeking University Research Center on Aging, Beijing 100191, China; Department of Biochemistry and Molecular Biology, Peking University Health Science Center, Beijing 100191, ChinaPeking University Research Center on Aging, Beijing 100191, China; Department of Biochemistry and Molecular Biology, Peking University Health Science Center, Beijing 100191, ChinaMOE Key Laboratory of Bioinformatics, Cell Biology and Development Center, School of Life Sciences, Tsinghua University, Beijing 100084, ChinaMOE Key Laboratory of Bioinformatics, Cell Biology and Development Center, School of Life Sciences, Tsinghua University, Beijing 100084, ChinaMOE Key Laboratory of Bioinformatics, Cell Biology and Development Center, School of Life Sciences, Tsinghua University, Beijing 100084, China; Corresponding authorSummary: Mitochondrial dysfunctions play major roles in many diseases. However, how mitochondrial stresses are relayed to downstream responses remains unclear. Here we show that the RNA component of mammalian telomerase TERC is imported into mitochondria, processed to a shorter form TERC-53, and then exported back to the cytosol. We found that the import is regulated by PNPASE, and the processing is controlled by mitochondrion-localized RNASET2. Cytosolic TERC-53 levels respond to changes in mitochondrial functions but have no direct effect on these functions. These findings uncover a mitochondrial RNA trafficking pathway and provide a potential mechanism for mitochondria to relay their functional states to other cellular compartments. : The functions of most mitochondrial RNAs imported from the cytosol are poorly understood. Cheng et al. provide evidence that the RNA component of mammalian telomerase TERC is imported into mitochondria, processed to a shorter form TERC-53, and then exported back to the cytosol. The cytosolic TERC-53 level serves as a potential indicator of mitochondrial functions. Keywords: mitochondria, RNA, import, export, processing, mitochondrial dysfunction, retrograde signaling, TERC, telomerase, RNASET2http://www.sciencedirect.com/science/article/pii/S2211124718312440 |
| spellingShingle | Ying Cheng Peipei Liu Qian Zheng Ge Gao Jiapei Yuan Pengfeng Wang Jinliang Huang Leiming Xie Xinping Lu Tanjun Tong Jun Chen Zhi Lu Jisong Guan Geng Wang Mitochondrial Trafficking and Processing of Telomerase RNA TERC Cell Reports |
| title | Mitochondrial Trafficking and Processing of Telomerase RNA TERC |
| title_full | Mitochondrial Trafficking and Processing of Telomerase RNA TERC |
| title_fullStr | Mitochondrial Trafficking and Processing of Telomerase RNA TERC |
| title_full_unstemmed | Mitochondrial Trafficking and Processing of Telomerase RNA TERC |
| title_short | Mitochondrial Trafficking and Processing of Telomerase RNA TERC |
| title_sort | mitochondrial trafficking and processing of telomerase rna terc |
| url | http://www.sciencedirect.com/science/article/pii/S2211124718312440 |
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