ABL gene kinase domain mutation scanning by denaturing high performance liquid chromatography sequencing method

ABL gene kinase domain mutation scanning by denaturing high performance liquid chromatography sequencing method

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Objective: Despite the efficacy of the BCR-ABL tyrosine kinase inhibitor imatinib, the development of resistance against imatinib has been observed. The most important mechanisms known to cause resistance are point mutations in the ABL tyrosine kinase and the ATP domain. This study describes the use...

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Bibliographic Details
Main Authors: Yücel Erbilgin, Suzin Çatal, Ahmet Emre Eşkazan, Özden Hatırnaz, Teoman Soysal, Uğur Özbek
Format: Article
Language:English
Published: Galenos Publishing House 2011-06-01
Series:Turkish Journal of Hematology
Subjects:
Chronic myeloid leukemia
imatinib resistance
mutation
dHPLC
Online Access:http://www.journalagent.com/z4/download_fulltext.asp?pdir=tjh&plng=eng&un=TJH-44365

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http://www.journalagent.com/z4/download_fulltext.asp?pdir=tjh&plng=eng&un=TJH-44365

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