When Characteristics of Clinical Trials Require Per-Protocol as Well as Intention-to-Treat Outcomes to Draw Reliable Conclusions: Three Examples

When Characteristics of Clinical Trials Require Per-Protocol as Well as Intention-to-Treat Outcomes to Draw Reliable Conclusions: Three Examples

Under exceptional circumstances, including high rates of protocol non-compliance, per-protocol (PP) analysis can better indicate the real-world benefits of a medical intervention than intention-to-treat (ITT) analysis. Exemplifying this, the first randomized clinical trial (RCT) considered found tha...

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Bibliographic Details
Main Authors: David E. Scheim, Colleen Aldous, Barbara Osimani, Edmund J. Fordham, Wendy E. Hoy
Format: Article
Language:English
Published: MDPI AG 2023-05-01
Series:Journal of Clinical Medicine
Subjects:
intention-to-treat
per-protocol
colonoscopy
fluvoxamine
ivermectin
COVID-19
Online Access:https://www.mdpi.com/2077-0383/12/11/3625

Internet

https://www.mdpi.com/2077-0383/12/11/3625

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