When Characteristics of Clinical Trials Require Per-Protocol as Well as Intention-to-Treat Outcomes to Draw Reliable Conclusions: Three Examples
Under exceptional circumstances, including high rates of protocol non-compliance, per-protocol (PP) analysis can better indicate the real-world benefits of a medical intervention than intention-to-treat (ITT) analysis. Exemplifying this, the first randomized clinical trial (RCT) considered found tha...
Main Authors: | David E. Scheim, Colleen Aldous, Barbara Osimani, Edmund J. Fordham, Wendy E. Hoy |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2023-05-01
|
Series: | Journal of Clinical Medicine |
Subjects: | |
Online Access: | https://www.mdpi.com/2077-0383/12/11/3625 |
Similar Items
-
When Characteristics of Clinical Trials Require Per-Protocol as Well as Intention-to-Treat Outcomes to Draw Reliable Conclusions: Three Examples
by: Scheim, David E., et al.
Published: (2023) -
Intention-to-treat analysis may be more conservative than per protocol analysis in antibiotic non-inferiority trials: a systematic review
by: Anthony D. Bai, et al.
Published: (2021-04-01) -
Intention-to-treat concept: A review
by: Sandeep K Gupta
Published: (2011-01-01) -
Utility of sustainable ratio derivative spectrophotometry for the concurrent assay of synergistic repurposed drugs for COVID-19 infections; Insilico pharmacokinetics proof
by: Sara I. Aboras, et al.
Published: (2024-03-01) -
Two-week triple therapy has a higher Helicobacter pylori eradication rate than 1-week therapy: A single-center randomized study
by: Jiaofeng Wang, et al.
Published: (2015-01-01)