Construction of MOFs nanoplatform with pH-triggered release of protocatechuic acid for intervertebral disc degeneration therapy

Construction of MOFs nanoplatform with pH-triggered release of protocatechuic acid for intervertebral disc degeneration therapy

Lower back pain is a significant contributor to disability and incapacity in adults. Up to 40 % of lower back pain is considered to be caused primarily by disc degeneration. The pH value in the intervertebral disc (IVD) usually decreases with the progression of degeneration, which can act as an init...

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Bibliographic Details
Main Authors: Hong Ding, Xiang Zhang, Zheng Liu, Juehan Wang, Ce Zhu, Qian Chen, Yong Huang, Youwei Ai, Ruibang Wu, Ganjun Feng, Li Zhang, Limin Liu
Format: Article
Language:English
Published: Elsevier 2023-01-01
Series:Materials & Design
Subjects:
Intervertebral disc degeneration
Metal–organic framework
Protocatechuic acid
pH-response
Online Access:http://www.sciencedirect.com/science/article/pii/S0264127522011169

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http://www.sciencedirect.com/science/article/pii/S0264127522011169

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