Construction of MOFs nanoplatform with pH-triggered release of protocatechuic acid for intervertebral disc degeneration therapy
Lower back pain is a significant contributor to disability and incapacity in adults. Up to 40 % of lower back pain is considered to be caused primarily by disc degeneration. The pH value in the intervertebral disc (IVD) usually decreases with the progression of degeneration, which can act as an init...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-01-01
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| Series: | Materials & Design |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0264127522011169 |
| _version_ | 1811175509964357632 |
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| author | Hong Ding Xiang Zhang Zheng Liu Juehan Wang Ce Zhu Qian Chen Yong Huang Youwei Ai Ruibang Wu Ganjun Feng Li Zhang Limin Liu |
| author_facet | Hong Ding Xiang Zhang Zheng Liu Juehan Wang Ce Zhu Qian Chen Yong Huang Youwei Ai Ruibang Wu Ganjun Feng Li Zhang Limin Liu |
| author_sort | Hong Ding |
| collection | DOAJ |
| description | Lower back pain is a significant contributor to disability and incapacity in adults. Up to 40 % of lower back pain is considered to be caused primarily by disc degeneration. The pH value in the intervertebral disc (IVD) usually decreases with the progression of degeneration, which can act as an initiator to trigger the release of drugs precisely for inhibiting the intervertebral disc degeneration (IDD). Herein, we fabricated a pH-responsive metal organic framework (MOF) to load anti-inflammatory protocatechuic acid (PCA), followed by the encapsulation of hyaluronic acid (HA), the final product was abbreviated as MOF@PH. The results showed that the acidic microenvironment could trigger drug release from MOF@PH featured by an increasing release proportion with pH decreasing. The cell assessment indicated that MOF@PH could suppress the inflammatory response of the nucleus pulposus significantly, downregulate the expression of related inflammatory markers (IL-6, ROS, NLRP-3 etc.) and promote the expression of nucleus pulposus specific markers. The administration of MOF@PH in rat disc degeneration model was proven able to effectively delay the degeneration process. The pH-sensitive MOF@PH may offer an effective strategy to precisely treat the IDD with desired therapeutic effects. |
| first_indexed | 2024-04-10T19:37:04Z |
| format | Article |
| id | doaj.art-dc6758f1694443e49a9714d3dba1dc3c |
| institution | Directory Open Access Journal |
| issn | 0264-1275 |
| language | English |
| last_indexed | 2024-04-10T19:37:04Z |
| publishDate | 2023-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials & Design |
| spelling | doaj.art-dc6758f1694443e49a9714d3dba1dc3c2023-01-30T04:12:14ZengElsevierMaterials & Design0264-12752023-01-01225111493Construction of MOFs nanoplatform with pH-triggered release of protocatechuic acid for intervertebral disc degeneration therapyHong Ding0Xiang Zhang1Zheng Liu2Juehan Wang3Ce Zhu4Qian Chen5Yong Huang6Youwei Ai7Ruibang Wu8Ganjun Feng9Li Zhang10Limin Liu11Department of Orthopedics Surgery and Orthopedic Research Institute, West China Hospital, Analytical & Testing Center, Sichuan University, Chengdu 610065, ChinaDepartment of Orthopedics Surgery and Orthopedic Research Institute, West China Hospital, Analytical & Testing Center, Sichuan University, Chengdu 610065, ChinaDepartment of Orthopedics Surgery and Orthopedic Research Institute, West China Hospital, Analytical & Testing Center, Sichuan University, Chengdu 610065, ChinaDepartment of Orthopedics Surgery and Orthopedic Research Institute, West China Hospital, Analytical & Testing Center, Sichuan University, Chengdu 610065, ChinaDepartment of Orthopedics Surgery and Orthopedic Research Institute, West China Hospital, Analytical & Testing Center, Sichuan University, Chengdu 610065, ChinaDepartment of Orthopedics Surgery and Orthopedic Research Institute, West China Hospital, Analytical & Testing Center, Sichuan University, Chengdu 610065, ChinaDepartment of Orthopedics Surgery and Orthopedic Research Institute, West China Hospital, Analytical & Testing Center, Sichuan University, Chengdu 610065, ChinaDepartment of Orthopedics Surgery and Orthopedic Research Institute, West China Hospital, Analytical & Testing Center, Sichuan University, Chengdu 610065, ChinaDepartment of Orthopedics Surgery and Orthopedic Research Institute, West China Hospital, Analytical & Testing Center, Sichuan University, Chengdu 610065, ChinaCorresponding authors.; Department of Orthopedics Surgery and Orthopedic Research Institute, West China Hospital, Analytical & Testing Center, Sichuan University, Chengdu 610065, ChinaCorresponding authors.; Department of Orthopedics Surgery and Orthopedic Research Institute, West China Hospital, Analytical & Testing Center, Sichuan University, Chengdu 610065, ChinaCorresponding authors.; Department of Orthopedics Surgery and Orthopedic Research Institute, West China Hospital, Analytical & Testing Center, Sichuan University, Chengdu 610065, ChinaLower back pain is a significant contributor to disability and incapacity in adults. Up to 40 % of lower back pain is considered to be caused primarily by disc degeneration. The pH value in the intervertebral disc (IVD) usually decreases with the progression of degeneration, which can act as an initiator to trigger the release of drugs precisely for inhibiting the intervertebral disc degeneration (IDD). Herein, we fabricated a pH-responsive metal organic framework (MOF) to load anti-inflammatory protocatechuic acid (PCA), followed by the encapsulation of hyaluronic acid (HA), the final product was abbreviated as MOF@PH. The results showed that the acidic microenvironment could trigger drug release from MOF@PH featured by an increasing release proportion with pH decreasing. The cell assessment indicated that MOF@PH could suppress the inflammatory response of the nucleus pulposus significantly, downregulate the expression of related inflammatory markers (IL-6, ROS, NLRP-3 etc.) and promote the expression of nucleus pulposus specific markers. The administration of MOF@PH in rat disc degeneration model was proven able to effectively delay the degeneration process. The pH-sensitive MOF@PH may offer an effective strategy to precisely treat the IDD with desired therapeutic effects.http://www.sciencedirect.com/science/article/pii/S0264127522011169Intervertebral disc degenerationMetal–organic frameworkProtocatechuic acidpH-response |
| spellingShingle | Hong Ding Xiang Zhang Zheng Liu Juehan Wang Ce Zhu Qian Chen Yong Huang Youwei Ai Ruibang Wu Ganjun Feng Li Zhang Limin Liu Construction of MOFs nanoplatform with pH-triggered release of protocatechuic acid for intervertebral disc degeneration therapy Materials & Design Intervertebral disc degeneration Metal–organic framework Protocatechuic acid pH-response |
| title | Construction of MOFs nanoplatform with pH-triggered release of protocatechuic acid for intervertebral disc degeneration therapy |
| title_full | Construction of MOFs nanoplatform with pH-triggered release of protocatechuic acid for intervertebral disc degeneration therapy |
| title_fullStr | Construction of MOFs nanoplatform with pH-triggered release of protocatechuic acid for intervertebral disc degeneration therapy |
| title_full_unstemmed | Construction of MOFs nanoplatform with pH-triggered release of protocatechuic acid for intervertebral disc degeneration therapy |
| title_short | Construction of MOFs nanoplatform with pH-triggered release of protocatechuic acid for intervertebral disc degeneration therapy |
| title_sort | construction of mofs nanoplatform with ph triggered release of protocatechuic acid for intervertebral disc degeneration therapy |
| topic | Intervertebral disc degeneration Metal–organic framework Protocatechuic acid pH-response |
| url | http://www.sciencedirect.com/science/article/pii/S0264127522011169 |
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