Constitutive β-catenin signaling by the viral chemokine receptor US28.
Chronic activation of Wnt/β-catenin signaling is found in a variety of human malignancies including melanoma, colorectal and hepatocellular carcinomas. Interestingly, expression of the HCMV-encoded chemokine receptor US28 in intestinal epithelial cells promotes intestinal neoplasia in transgenic mic...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2012-01-01
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| Series: | PLoS ONE |
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23145028/?tool=EBI |
| _version_ | 1818701025777811456 |
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| author | Ellen V Langemeijer Erik Slinger Sabrina de Munnik Andreas Schreiber David Maussang Henry Vischer Folkert Verkaar Rob Leurs Marco Siderius Martine J Smit |
| author_facet | Ellen V Langemeijer Erik Slinger Sabrina de Munnik Andreas Schreiber David Maussang Henry Vischer Folkert Verkaar Rob Leurs Marco Siderius Martine J Smit |
| author_sort | Ellen V Langemeijer |
| collection | DOAJ |
| description | Chronic activation of Wnt/β-catenin signaling is found in a variety of human malignancies including melanoma, colorectal and hepatocellular carcinomas. Interestingly, expression of the HCMV-encoded chemokine receptor US28 in intestinal epithelial cells promotes intestinal neoplasia in transgenic mice, which is associated with increased nuclear accumulation of β-catenin. In this study we show that this viral receptor constitutively activates β-catenin and enhances β-catenin-dependent transcription. Our data illustrate that this viral receptor does not activate β-catenin via the classical Wnt/Frizzled signaling pathway. Analysis of US28 mediated signaling indicates the involvement of the Rho-Rho kinase (ROCK) pathway in the activation of β-catenin. Moreover, cells infected with HCMV show significant increases in β-catenin stabilization and signaling, which is mediated to a large extent by expression of US28. The modulation of the β-catenin signal transduction pathway by a viral chemokine receptor provides alternative regulation of this pathway, with potential relevance for the development of colon cancer and virus-associated diseases. |
| first_indexed | 2024-12-17T15:14:17Z |
| format | Article |
| id | doaj.art-dc6c07a9a5084249b47881e5dc3e6aaf |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-17T15:14:17Z |
| publishDate | 2012-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-dc6c07a9a5084249b47881e5dc3e6aaf2022-12-21T21:43:35ZengPublic Library of Science (PLoS)PLoS ONE1932-62032012-01-01711e4893510.1371/journal.pone.0048935Constitutive β-catenin signaling by the viral chemokine receptor US28.Ellen V LangemeijerErik SlingerSabrina de MunnikAndreas SchreiberDavid MaussangHenry VischerFolkert VerkaarRob LeursMarco SideriusMartine J SmitChronic activation of Wnt/β-catenin signaling is found in a variety of human malignancies including melanoma, colorectal and hepatocellular carcinomas. Interestingly, expression of the HCMV-encoded chemokine receptor US28 in intestinal epithelial cells promotes intestinal neoplasia in transgenic mice, which is associated with increased nuclear accumulation of β-catenin. In this study we show that this viral receptor constitutively activates β-catenin and enhances β-catenin-dependent transcription. Our data illustrate that this viral receptor does not activate β-catenin via the classical Wnt/Frizzled signaling pathway. Analysis of US28 mediated signaling indicates the involvement of the Rho-Rho kinase (ROCK) pathway in the activation of β-catenin. Moreover, cells infected with HCMV show significant increases in β-catenin stabilization and signaling, which is mediated to a large extent by expression of US28. The modulation of the β-catenin signal transduction pathway by a viral chemokine receptor provides alternative regulation of this pathway, with potential relevance for the development of colon cancer and virus-associated diseases.https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23145028/?tool=EBI |
| spellingShingle | Ellen V Langemeijer Erik Slinger Sabrina de Munnik Andreas Schreiber David Maussang Henry Vischer Folkert Verkaar Rob Leurs Marco Siderius Martine J Smit Constitutive β-catenin signaling by the viral chemokine receptor US28. PLoS ONE |
| title | Constitutive β-catenin signaling by the viral chemokine receptor US28. |
| title_full | Constitutive β-catenin signaling by the viral chemokine receptor US28. |
| title_fullStr | Constitutive β-catenin signaling by the viral chemokine receptor US28. |
| title_full_unstemmed | Constitutive β-catenin signaling by the viral chemokine receptor US28. |
| title_short | Constitutive β-catenin signaling by the viral chemokine receptor US28. |
| title_sort | constitutive β catenin signaling by the viral chemokine receptor us28 |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23145028/?tool=EBI |
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