Time dependent response of daunorubicin on cytotoxicity, cell cycle and DNA repair in acute lymphoblastic leukaemia

Time dependent response of daunorubicin on cytotoxicity, cell cycle and DNA repair in acute lymphoblastic leukaemia

Abstract Background Daunorubicin is commonly used in the treatment of acute lymphoblastic leukaemia (ALL). The aim of this study was to explore the kinetics of double strand break (DSB) formation of three ALL cell lines following exposure to daunorubicin and to investigate the effects of daunorubici...

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Bibliographic Details
Main Authors: Hussain Mubarak Al-Aamri, Heng Ku, Helen R. Irving, Joseph Tucci, Terri Meehan-Andrews, Christopher Bradley
Format: Article
Language:English
Published: BMC 2019-02-01
Series:BMC Cancer
Subjects:
Ataxia–telangiectasia mutated (ATM)
DNA double strand breaks (DSB)
γH2AX
p53
Reactive oxygen species (ROS)
Superoxide dismutase (SOD2)
Online Access:http://link.springer.com/article/10.1186/s12885-019-5377-y

Internet

http://link.springer.com/article/10.1186/s12885-019-5377-y

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