Intranasally delivered mesenchymal stromal cells decrease glial inflammation early in prion disease

Intranasally delivered mesenchymal stromal cells decrease glial inflammation early in prion disease

Mesenchymal stromal cells (MSCs) are an intriguing avenue for the treatment of neurological disorders due to their ability to migrate to sites of neuroinflammation and respond to paracrine signaling in those sites by secreting cytokines, growth factors, and other neuromodulators. We potentiated this...

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Bibliographic Details
Main Authors: Arielle J. D. Hay, Amanda S. Latham, Genova Mumford, Amelia D. Hines, Sydney Risen, Elizabeth Gordon, Connor Siebenaler, Vincenzo S. Gilberto, Mark D. Zabel, Julie A. Moreno
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-05-01
Series:Frontiers in Neuroscience
Subjects:
microglia
astrocytes
prion
inflammation
cytokines
mesenchymal stromal cells
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2023.1158408/full

Internet

https://www.frontiersin.org/articles/10.3389/fnins.2023.1158408/full

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