Age Worsens the Cognitive Phenotype in Mice Carrying the Thr92Ala-DIO2 Polymorphism

Age Worsens the Cognitive Phenotype in Mice Carrying the Thr92Ala-DIO2 Polymorphism

The Thr92Ala-Dio2 polymorphism has been associated with reduced cognition in 2-month-old male mice and increased risk for cognitive impairment and Alzheimer’s disease in African Americans. This has been attributed to reduced thyroid hormone (TH) signaling and endoplasmic reticulum (ER) stress in the...

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Bibliographic Details
Main Authors: Fernanda B. Lorena, Juliana M. Sato, Beatriz Martin Coviello, Alexandre J. T. Arnold, Alice Batistuzzo, Laís M. Yamanouchi, Eduardo Dias Junior, Bruna P. P. do Nascimento, Tatiana de L. Fonseca, Antonio C. Bianco, Miriam O. Ribeiro
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:Metabolites
Subjects:
thyroid hormone
cognition
type 2 deiodinase
Online Access:https://www.mdpi.com/2218-1989/12/7/629

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https://www.mdpi.com/2218-1989/12/7/629

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