The PKG Inhibitor CN238 Affords Functional Protection of Photoreceptors and Ganglion Cells against Retinal Degeneration

The PKG Inhibitor CN238 Affords Functional Protection of Photoreceptors and Ganglion Cells against Retinal Degeneration

Hereditary retinal degeneration (RD) is often associated with excessive cGMP signalling in photoreceptors. Previous research has shown that inhibition of cGMP-dependent protein kinase G (PKG) can reduce photoreceptor loss in two different RD animal models. In this study, we identified a PKG inhibito...

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Bibliographic Details
Main Authors: Arianna Tolone, Wadood Haq, Alexandra Fachinger, Akanksha Roy, Sandeep Kesh, Andreas Rentsch, Sophie Wucherpfennig, Yu Zhu, John Groten, Frank Schwede, Tushar Tomar, Friedrich W. Herberg, Vasilica Nache, François Paquet-Durand
Format: Article
Language:English
Published: MDPI AG 2023-10-01
Series:International Journal of Molecular Sciences
Subjects:
neuroprotection
retinitis pigmentosa
cGMP
PKG or PKG1
Kv1.3
Kv1.6
Online Access:https://www.mdpi.com/1422-0067/24/20/15277

Internet

https://www.mdpi.com/1422-0067/24/20/15277

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