The mitochondrial gene-CMPK2 functions as a rheostat for macrophage homeostasis

The mitochondrial gene-CMPK2 functions as a rheostat for macrophage homeostasis

In addition to their role in cellular energy production, mitochondria are increasingly recognized as regulators of the innate immune response of phagocytes. Here, we demonstrate that altering expression levels of the mitochondria-associated enzyme, cytidine monophosphate kinase 2 (CMPK2), disrupts m...

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Bibliographic Details
Main Authors: Prabhakar Arumugam, Meghna Chauhan, Thejaswitha Rajeev, Rahul Chakraborty, Kanika Bisht, Mahima Madan, Deepthi Shankaran, Sivaprakash Ramalingam, Sheetal Gandotra, Vivek Rao
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-11-01
Series:Frontiers in Immunology
Subjects:
CMPK2
M1 macrophage
immuno-metabolism
mitochondria
infection
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.935710/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.935710/full

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