Curcumin attenuates renal interstitial fibrosis of obstructive nephropathy by suppressing epithelial-mesenchymal transition through inhibition of the TLR4/NF-кB and PI3K/AKT signalling pathways

Curcumin attenuates renal interstitial fibrosis of obstructive nephropathy by suppressing epithelial-mesenchymal transition through inhibition of the TLR4/NF-кB and PI3K/AKT signalling pathways

Context Renal interstitial fibrosis (RIF) is characterized by the accumulation of inflammatory cytokines and epithelial-mesenchymal transition (EMT). Curcumin exerts antifibrogenic, anti-inflammatory and antiproliferative effects. Objective To explore the mechanisms underlying the effects of curcumi...

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Bibliographic Details
Main Authors: Zhaohui Wang, Zhi Chen, Bingsheng Li, Bo Zhang, Yongchao Du, Yuhang Liu, Yao He, Xiang Chen
Format: Article
Language:English
Published: Taylor & Francis Group 2020-01-01
Series:Pharmaceutical Biology
Subjects:
inflammation
unilateral ureteral obstruction
lipopolysaccharides
transforming growth factor beta 1
Online Access:http://dx.doi.org/10.1080/13880209.2020.1809462

Internet

http://dx.doi.org/10.1080/13880209.2020.1809462

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