Urolithin A (UA) attenuates ferroptosis in LPS-induced acute lung injury in mice by upregulating Keap1-Nrf2/HO-1 signaling pathway

Urolithin A (UA) attenuates ferroptosis in LPS-induced acute lung injury in mice by upregulating Keap1-Nrf2/HO-1 signaling pathway

Acute lung injury (ALI) is a life-threatening disease with high incidence and mortality rates. Urolithin A (UA) is a pomegranate intestinal flora metabolite with anti-inflammatory, antioxidant, and anti-aging properties. Ferroptosis is a critical factor in lipopolysaccharide (LPS)-induced acute lung...

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Bibliographic Details
Main Authors: Lejing Lou, Min Wang, Jingjing He, Song Yang, Fanxi Meng, Shijia Wang, Xiao Jin, Jihao Cai, Chang Cai
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Pharmacology
Subjects:
urolithin a
Nrf2
ferroptosis
acute lung injury
LPS
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1067402/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2023.1067402/full

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