Partially Hydrolyzed Guar Gum Suppresses the Development of Sarcopenic Obesity
Partially hydrolyzed guar gum (PHGG) is a soluble dietary fiber derived through controlled enzymatic hydrolysis of guar gum, a highly viscous galactomannan derived from the seeds of <i>Cyamopsis tetragonoloba</i>. Here, we examined the therapeutic potential of dietary supplementation wit...
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MDPI AG
2022-03-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/14/6/1157 |
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| author | Takuro Okamura Masahide Hamaguchi Jun Mori Mihoko Yamaguchi Katsura Mizushima Aya Abe Makoto Ozeki Ryoichi Sasano Yuji Naito Michiaki Fukui |
| author_facet | Takuro Okamura Masahide Hamaguchi Jun Mori Mihoko Yamaguchi Katsura Mizushima Aya Abe Makoto Ozeki Ryoichi Sasano Yuji Naito Michiaki Fukui |
| author_sort | Takuro Okamura |
| collection | DOAJ |
| description | Partially hydrolyzed guar gum (PHGG) is a soluble dietary fiber derived through controlled enzymatic hydrolysis of guar gum, a highly viscous galactomannan derived from the seeds of <i>Cyamopsis tetragonoloba</i>. Here, we examined the therapeutic potential of dietary supplementation with PHGG against sarcopenic obesity using Db/Db mice. Db/Db mice fed a normal diet alone or a fiber-free diet, or supplemented with a diet containing PHGG (5%), were examined. PHGG increased grip strength and the weight of skeletal muscles. PHGG increased the short-chain fatty acids (SCFAs) concentration in feces and sera. Concerning innate immunity, PHGG decreased the ratio of inflammatory cells, while increasing the ratio of anti-inflammatory cells in the small intestine. The present study demonstrated the preventive effect of PHGG on sarcopenic obesity. Changes in nutrient absorption might be involved through the promotion of an anti-inflammatory shift of innate immunity in the intestine accompanied by an increase in SCFA production by PHGG. |
| first_indexed | 2024-03-09T13:06:08Z |
| format | Article |
| id | doaj.art-dc7c378fda5842af9094ed5f07fb3f75 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-09T13:06:08Z |
| publishDate | 2022-03-01 |
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| series | Nutrients |
| spelling | doaj.art-dc7c378fda5842af9094ed5f07fb3f752023-11-30T21:48:45ZengMDPI AGNutrients2072-66432022-03-01146115710.3390/nu14061157Partially Hydrolyzed Guar Gum Suppresses the Development of Sarcopenic ObesityTakuro Okamura0Masahide Hamaguchi1Jun Mori2Mihoko Yamaguchi3Katsura Mizushima4Aya Abe5Makoto Ozeki6Ryoichi Sasano7Yuji Naito8Michiaki Fukui9Department of Endocrinology and Metabolism, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto 602-8566, JapanDepartment of Endocrinology and Metabolism, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto 602-8566, JapanDepartment of Pediatrics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto 602-8566, JapanDepartment of Pediatrics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto 602-8566, JapanDepartment of Human Immunology and Nutrition Science, Kyoto Prefectural University of Medicine, Kyoto 602-8566, JapanNutrition Division, Taiyo Kagaku Co., Ltd., Yokkaichi 510-0844, JapanNutrition Division, Taiyo Kagaku Co., Ltd., Yokkaichi 510-0844, JapanAiSTI Science Co., Ltd., Wakayama 640-8390, JapanDepartment of Human Immunology and Nutrition Science, Kyoto Prefectural University of Medicine, Kyoto 602-8566, JapanDepartment of Endocrinology and Metabolism, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto 602-8566, JapanPartially hydrolyzed guar gum (PHGG) is a soluble dietary fiber derived through controlled enzymatic hydrolysis of guar gum, a highly viscous galactomannan derived from the seeds of <i>Cyamopsis tetragonoloba</i>. Here, we examined the therapeutic potential of dietary supplementation with PHGG against sarcopenic obesity using Db/Db mice. Db/Db mice fed a normal diet alone or a fiber-free diet, or supplemented with a diet containing PHGG (5%), were examined. PHGG increased grip strength and the weight of skeletal muscles. PHGG increased the short-chain fatty acids (SCFAs) concentration in feces and sera. Concerning innate immunity, PHGG decreased the ratio of inflammatory cells, while increasing the ratio of anti-inflammatory cells in the small intestine. The present study demonstrated the preventive effect of PHGG on sarcopenic obesity. Changes in nutrient absorption might be involved through the promotion of an anti-inflammatory shift of innate immunity in the intestine accompanied by an increase in SCFA production by PHGG.https://www.mdpi.com/2072-6643/14/6/1157partially hydrolyzed guar gumPHGGsarcopenic obesitymetaboliteinnate immunity |
| spellingShingle | Takuro Okamura Masahide Hamaguchi Jun Mori Mihoko Yamaguchi Katsura Mizushima Aya Abe Makoto Ozeki Ryoichi Sasano Yuji Naito Michiaki Fukui Partially Hydrolyzed Guar Gum Suppresses the Development of Sarcopenic Obesity Nutrients partially hydrolyzed guar gum PHGG sarcopenic obesity metabolite innate immunity |
| title | Partially Hydrolyzed Guar Gum Suppresses the Development of Sarcopenic Obesity |
| title_full | Partially Hydrolyzed Guar Gum Suppresses the Development of Sarcopenic Obesity |
| title_fullStr | Partially Hydrolyzed Guar Gum Suppresses the Development of Sarcopenic Obesity |
| title_full_unstemmed | Partially Hydrolyzed Guar Gum Suppresses the Development of Sarcopenic Obesity |
| title_short | Partially Hydrolyzed Guar Gum Suppresses the Development of Sarcopenic Obesity |
| title_sort | partially hydrolyzed guar gum suppresses the development of sarcopenic obesity |
| topic | partially hydrolyzed guar gum PHGG sarcopenic obesity metabolite innate immunity |
| url | https://www.mdpi.com/2072-6643/14/6/1157 |
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