Folic Acid and Vitamin B12 Prevent Deleterious Effects of Rotenone on Object Novelty Recognition Memory and <i>Kynu</i> Expression in an Animal Model of Parkinson’s Disease

Folic Acid and Vitamin B12 Prevent Deleterious Effects of Rotenone on Object Novelty Recognition Memory and <i>Kynu</i> Expression in an Animal Model of Parkinson’s Disease

Parkinson’s disease (PD) is characterized by a range of motor signs, but cognitive dysfunction is also observed. Supplementation with folic acid and vitamin B12 is expected to prevent cognitive impairment. To test this in PD, we promoted a lesion within the substantia nigra <i>pars compacta<...

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Bibliographic Details
Main Authors: Gabriela Canalli Kretzschmar, Adriano D. S. Targa, Sheila Coelho Soares-Lima, Priscila Ianzen dos Santos, Lais S. Rodrigues, Daniel A. Macedo, Luis Felipe Ribeiro Pinto, Marcelo M. S. Lima, Angelica Beate Winter Boldt
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Genes
Subjects:
tryptophan pathway
DNA methylation
gene expression
neurodegenerative diseases
<i>Kynu</i>
cognitive impairment
Online Access:https://www.mdpi.com/2073-4425/13/12/2397

Internet

https://www.mdpi.com/2073-4425/13/12/2397

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