LEVODOPA PLUS CARBIDOPA: IS IT EFFECTIVE IN NONARTERITIC ANTERIOR ISCHEMIC OPTIC NEUROPATHY MANAGEMENT?
Introduction. Nonarteritic anterior ischemic optic neuropathy (NAION) is one of the causes of irreversible visual loss. As yet many treatment modalities are used for therapy, but non of them have had significant effect on recovery of visual acuity. To study levodopa plus carbidopa effect on NAION, t...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2000-03-01
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| Series: | Journal of Research in Medical Sciences |
| Subjects: | |
| Online Access: | http://journals.mui.ac.ir/jrms/article/view/3498 |
| _version_ | 1831690250952376320 |
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| author | H GHANBARI A DEHGHANI |
| author_facet | H GHANBARI A DEHGHANI |
| author_sort | H GHANBARI |
| collection | DOAJ |
| description | Introduction. Nonarteritic anterior ischemic optic neuropathy (NAION) is one of the causes of irreversible visual loss. As yet many treatment modalities are used for therapy, but non of them have had significant effect on recovery of visual acuity. To study levodopa plus carbidopa effect on NAION, this research was done. Methods. In this clinical trial double blind study, two groups (each contained 20 subjects) recieved randomly 100 mg levodopa + 10 mg carbidopa and placebo per day for 3 weeks. Subjects were followed up at 6, 12, 24 weeks after treatment for assess visual acuity. Findings. The mean differences of visual acuity between initial and 24 weeks later in interventional and control group were 4.6/100± 7.373/100 and 10.35/100± 17.572/100 respectively (P>0.05). Conclusion. There was not any effect of drug on recovery of visual acuity. Thus, due to their side effects, levodopa and carbidopa not recommended in NAION management. |
| first_indexed | 2024-12-20T11:06:05Z |
| format | Article |
| id | doaj.art-dc8178f89013479ba6be0bb5a755e914 |
| institution | Directory Open Access Journal |
| issn | 1735-1995 1735-7136 |
| language | English |
| last_indexed | 2024-12-20T11:06:05Z |
| publishDate | 2000-03-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Research in Medical Sciences |
| spelling | doaj.art-dc8178f89013479ba6be0bb5a755e9142022-12-21T19:42:52ZengWolters Kluwer Medknow PublicationsJournal of Research in Medical Sciences1735-19951735-71362000-03-0151LEVODOPA PLUS CARBIDOPA: IS IT EFFECTIVE IN NONARTERITIC ANTERIOR ISCHEMIC OPTIC NEUROPATHY MANAGEMENT?H GHANBARIA DEHGHANIIntroduction. Nonarteritic anterior ischemic optic neuropathy (NAION) is one of the causes of irreversible visual loss. As yet many treatment modalities are used for therapy, but non of them have had significant effect on recovery of visual acuity. To study levodopa plus carbidopa effect on NAION, this research was done. Methods. In this clinical trial double blind study, two groups (each contained 20 subjects) recieved randomly 100 mg levodopa + 10 mg carbidopa and placebo per day for 3 weeks. Subjects were followed up at 6, 12, 24 weeks after treatment for assess visual acuity. Findings. The mean differences of visual acuity between initial and 24 weeks later in interventional and control group were 4.6/100± 7.373/100 and 10.35/100± 17.572/100 respectively (P>0.05). Conclusion. There was not any effect of drug on recovery of visual acuity. Thus, due to their side effects, levodopa and carbidopa not recommended in NAION management.http://journals.mui.ac.ir/jrms/article/view/3498Nonarteritic Anterior Ischemic Optic Neuropathy, Levodopa, Carbidopa, Visual loss |
| spellingShingle | H GHANBARI A DEHGHANI LEVODOPA PLUS CARBIDOPA: IS IT EFFECTIVE IN NONARTERITIC ANTERIOR ISCHEMIC OPTIC NEUROPATHY MANAGEMENT? Journal of Research in Medical Sciences Nonarteritic Anterior Ischemic Optic Neuropathy, Levodopa, Carbidopa, Visual loss |
| title | LEVODOPA PLUS CARBIDOPA: IS IT EFFECTIVE IN NONARTERITIC ANTERIOR ISCHEMIC OPTIC NEUROPATHY MANAGEMENT? |
| title_full | LEVODOPA PLUS CARBIDOPA: IS IT EFFECTIVE IN NONARTERITIC ANTERIOR ISCHEMIC OPTIC NEUROPATHY MANAGEMENT? |
| title_fullStr | LEVODOPA PLUS CARBIDOPA: IS IT EFFECTIVE IN NONARTERITIC ANTERIOR ISCHEMIC OPTIC NEUROPATHY MANAGEMENT? |
| title_full_unstemmed | LEVODOPA PLUS CARBIDOPA: IS IT EFFECTIVE IN NONARTERITIC ANTERIOR ISCHEMIC OPTIC NEUROPATHY MANAGEMENT? |
| title_short | LEVODOPA PLUS CARBIDOPA: IS IT EFFECTIVE IN NONARTERITIC ANTERIOR ISCHEMIC OPTIC NEUROPATHY MANAGEMENT? |
| title_sort | levodopa plus carbidopa is it effective in nonarteritic anterior ischemic optic neuropathy management |
| topic | Nonarteritic Anterior Ischemic Optic Neuropathy, Levodopa, Carbidopa, Visual loss |
| url | http://journals.mui.ac.ir/jrms/article/view/3498 |
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