Emergence of Ebola Virus Escape Variants in Infected Nonhuman Primates Treated with the MB-003 Antibody Cocktail

Emergence of Ebola Virus Escape Variants in Infected Nonhuman Primates Treated with the MB-003 Antibody Cocktail

MB-003, a plant-derived monoclonal antibody cocktail used effectively in treatment of Ebola virus infection in non-human primates, was unable to protect two of six animals when initiated 1 or 2 days post-infection. We characterized a mechanism of viral escape in one of the animals, after observation...

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Bibliographic Details
Main Authors: Jeffrey R. Kugelman, Johanny Kugelman-Tonos, Jason T. Ladner, James Pettit, Carolyn M. Keeton, Elyse R. Nagle, Karla Y. Garcia, Jeffrey W. Froude, Ana I. Kuehne, Jens H. Kuhn, Sina Bavari, Larry Zeitlin, John M. Dye, Gene G. Olinger, Mariano Sanchez-Lockhart, Gustavo F. Palacios
Format: Article
Language:English
Published: Elsevier 2015-09-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124715009237

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http://www.sciencedirect.com/science/article/pii/S2211124715009237

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