Sitagliptin Stimulates Endothelial Progenitor Cells to Induce Endothelialization in Aneurysm Necks Through the SDF-1/CXCR4/NRF2 Signaling Pathway

Sitagliptin Stimulates Endothelial Progenitor Cells to Induce Endothelialization in Aneurysm Necks Through the SDF-1/CXCR4/NRF2 Signaling Pathway

Aneurysm (AN) embolization is an important treatment for cerebral aneurysms. The endothelialization of the aneurysm neck is crucial for preventing aneurysm recurrence. Sitagliptin is a therapeutic drug for diabetes that has been reported to have cardiovascular-protective effects. This study investig...

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Bibliographic Details
Main Authors: Guo Yu, Peixi Liu, Yuan Shi, Sichen Li, Yingjun Liu, Wei Zhu
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-11-01
Series:Frontiers in Endocrinology
Subjects:
sitagliptin
endothelial progenitor cells
aneurysm
SDF-1
CXCR4
NRF2
Online Access:https://www.frontiersin.org/article/10.3389/fendo.2019.00823/full

Internet

https://www.frontiersin.org/article/10.3389/fendo.2019.00823/full

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