Aberrant APOBEC3B Expression in Breast Cancer Is Linked to Proliferation and Cell Cycle Phase

Aberrant APOBEC3B Expression in Breast Cancer Is Linked to Proliferation and Cell Cycle Phase

APOBEC3B (A3B) is aberrantly overexpressed in a subset of breast cancers, where it associates with advanced disease, poor prognosis, and treatment resistance, yet the causes of A3B dysregulation in breast cancer remain unclear. Here, A3B mRNA and protein expression levels were quantified in differen...

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Bibliographic Details
Main Authors: Pieter A. Roelofs, Mieke A. M. Timmermans, Bojana Stefanovska, Myrthe A. den Boestert, Amber W. M. van den Borne, Hayri E. Balcioglu, Anita M. Trapman, Reuben S. Harris, John W. M. Martens, Paul N. Span
Format: Article
Language:English
Published: MDPI AG 2023-04-01
Series:Cells
Subjects:
APOBEC3B
cell cycle
transcription
G<sub>2</sub>/M
RB/E2F pathway
PKC/ncNF-κB pathway
Online Access:https://www.mdpi.com/2073-4409/12/8/1185

Internet

https://www.mdpi.com/2073-4409/12/8/1185

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