Blocking HMGB1/RAGE Signaling by Berberine Alleviates A1 Astrocyte and Attenuates Sepsis-Associated Encephalopathy

Blocking HMGB1/RAGE Signaling by Berberine Alleviates A1 Astrocyte and Attenuates Sepsis-Associated Encephalopathy

As a life-threatening multiple organ dysfunction attributable to maladjusted host immune responses to infection, sepsis is usually the common pathway to serious prognosis and death for numerous infectious diseases all over the world. Sepsis-associated encephalopathy (SAE) is frequently complicated b...

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Bibliographic Details
Main Authors: Jian Shi, Huan Xu, María José Cavagnaro, Xingmei Li, Jia Fang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-11-01
Series:Frontiers in Pharmacology
Subjects:
berberine
sepsis-associated encephalopathy
HMGB1/RAGE signaling
cognitive impairment
inflammatory cytokines
neuropharmacology
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.760186/full

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https://www.frontiersin.org/articles/10.3389/fphar.2021.760186/full

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