Non-flipping DNA glycosylase AlkD scans DNA without formation of a stable interrogation complex

Non-flipping DNA glycosylase AlkD scans DNA without formation of a stable interrogation complex

Ahmadi et al. use a single-molecule tracking method to describe the DNA scanning mode of AlkD, a HEAT-like repeat DNA glycosylase. They show that, contrary to other glycosylases that use a base-flipping mechanism, AlkD scans the DNA without forming a stable interrogation complex.

Bibliographic Details
Main Authors: Arash Ahmadi, Katharina Till, Paul Hoff Backe, Pernille Blicher, Robin Diekmann, Mark Schüttpelz, Kyrre Glette, Jim Tørresen, Magnar Bjørås, Alexander D. Rowe, Bjørn Dalhus
Format: Article
Language:English
Published: Nature Portfolio 2021-07-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-021-02400-x

Internet

https://doi.org/10.1038/s42003-021-02400-x

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