Three Amino Acid Substitutions in the Spike Protein Enable the Coronavirus Porcine Epidemic Diarrhea Virus To Infect Vero Cells

Three Amino Acid Substitutions in the Spike Protein Enable the Coronavirus Porcine Epidemic Diarrhea Virus To Infect Vero Cells

ABSTRACT Porcine epidemic diarrhea virus (PEDV), a continuously evolving pathogen, causes severe diarrhea in piglets, with high mortality rates. To prevent or mitigate the disease, it is common practice to develop live or inactivated PEDV vaccines based on cell-adapted viral variants. Propagating wi...

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Bibliographic Details
Main Authors: Bingqing Chen, Shijuan Dong, Li Yu, Fusheng Si, Chunhua Li, Chunfang Xie, Ruisong Yu, Zhen Li
Format: Article
Language:English
Published: American Society for Microbiology 2023-02-01
Series:Microbiology Spectrum
Subjects:
PEDV
cell adaptation
S protein
tropism
reverse genetics
Online Access:https://journals.asm.org/doi/10.1128/spectrum.03872-22

Internet

https://journals.asm.org/doi/10.1128/spectrum.03872-22

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