Construction of developmental lineage relationships in the mouse mammary gland by single-cell RNA profiling
The mammary epithelium comprises two cell lineages but the heterogeneity amongst these during development is unclear. Here, the authors report single-cell RNA sequencing of the mouse mammary epithelium at four developmental stages, revealing diversity in both compartments and a transcriptional shift...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2017-11-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-017-01560-x |
| _version_ | 1818990882353840128 |
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| author | Bhupinder Pal Yunshun Chen François Vaillant Paul Jamieson Lavinia Gordon Anne C. Rios Stephen Wilcox Naiyang Fu Kevin He Liu Felicity C. Jackling Melissa J. Davis Geoffrey J. Lindeman Gordon K. Smyth Jane E. Visvader |
| author_facet | Bhupinder Pal Yunshun Chen François Vaillant Paul Jamieson Lavinia Gordon Anne C. Rios Stephen Wilcox Naiyang Fu Kevin He Liu Felicity C. Jackling Melissa J. Davis Geoffrey J. Lindeman Gordon K. Smyth Jane E. Visvader |
| author_sort | Bhupinder Pal |
| collection | DOAJ |
| description | The mammary epithelium comprises two cell lineages but the heterogeneity amongst these during development is unclear. Here, the authors report single-cell RNA sequencing of the mouse mammary epithelium at four developmental stages, revealing diversity in both compartments and a transcriptional shift with puberty onset. |
| first_indexed | 2024-12-20T20:01:26Z |
| format | Article |
| id | doaj.art-dca0603f7480455abce0a865cd2cb6d0 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-20T20:01:26Z |
| publishDate | 2017-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-dca0603f7480455abce0a865cd2cb6d02022-12-21T19:28:03ZengNature PortfolioNature Communications2041-17232017-11-018111410.1038/s41467-017-01560-xConstruction of developmental lineage relationships in the mouse mammary gland by single-cell RNA profilingBhupinder Pal0Yunshun Chen1François Vaillant2Paul Jamieson3Lavinia Gordon4Anne C. Rios5Stephen Wilcox6Naiyang Fu7Kevin He Liu8Felicity C. Jackling9Melissa J. Davis10Geoffrey J. Lindeman11Gordon K. Smyth12Jane E. Visvader13ACRF Stem Cells and Cancer Division, The Walter and Eliza Hall Institute of Medical ResearchDepartment of Medical Biology, The University of MelbourneACRF Stem Cells and Cancer Division, The Walter and Eliza Hall Institute of Medical ResearchACRF Stem Cells and Cancer Division, The Walter and Eliza Hall Institute of Medical ResearchAustralian Genome Research Facility, The Walter and Eliza Hall Institute of Medical ResearchACRF Stem Cells and Cancer Division, The Walter and Eliza Hall Institute of Medical ResearchSystems Biology & Personalised Medicine Division, The Walter and Eliza Hall Institute of Medical ResearchACRF Stem Cells and Cancer Division, The Walter and Eliza Hall Institute of Medical ResearchACRF Stem Cells and Cancer Division, The Walter and Eliza Hall Institute of Medical ResearchACRF Stem Cells and Cancer Division, The Walter and Eliza Hall Institute of Medical ResearchBioinformatics Division, The Walter and Eliza Hall Institute of Medical ResearchACRF Stem Cells and Cancer Division, The Walter and Eliza Hall Institute of Medical ResearchBioinformatics Division, The Walter and Eliza Hall Institute of Medical ResearchACRF Stem Cells and Cancer Division, The Walter and Eliza Hall Institute of Medical ResearchThe mammary epithelium comprises two cell lineages but the heterogeneity amongst these during development is unclear. Here, the authors report single-cell RNA sequencing of the mouse mammary epithelium at four developmental stages, revealing diversity in both compartments and a transcriptional shift with puberty onset.https://doi.org/10.1038/s41467-017-01560-x |
| spellingShingle | Bhupinder Pal Yunshun Chen François Vaillant Paul Jamieson Lavinia Gordon Anne C. Rios Stephen Wilcox Naiyang Fu Kevin He Liu Felicity C. Jackling Melissa J. Davis Geoffrey J. Lindeman Gordon K. Smyth Jane E. Visvader Construction of developmental lineage relationships in the mouse mammary gland by single-cell RNA profiling Nature Communications |
| title | Construction of developmental lineage relationships in the mouse mammary gland by single-cell RNA profiling |
| title_full | Construction of developmental lineage relationships in the mouse mammary gland by single-cell RNA profiling |
| title_fullStr | Construction of developmental lineage relationships in the mouse mammary gland by single-cell RNA profiling |
| title_full_unstemmed | Construction of developmental lineage relationships in the mouse mammary gland by single-cell RNA profiling |
| title_short | Construction of developmental lineage relationships in the mouse mammary gland by single-cell RNA profiling |
| title_sort | construction of developmental lineage relationships in the mouse mammary gland by single cell rna profiling |
| url | https://doi.org/10.1038/s41467-017-01560-x |
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