The importance of targeting signalling mechanisms of the SLC39A family of zinc transporters to inhibit endocrine resistant breast cancer

Aim: Zinc is a key secondary messenger that can regulate multiple signalling pathways within cancer cells, thus its levels need to be strictly controlled. The Zrt, Irt-like protein (ZIP, SLC39A) family of zinc transporters increase cytosolic zinc from either extracellular or intracellular stores. T...

Full description

Bibliographic Details
Main Authors: Samuel Jones, Georgia Farr, Thirayost Nimmanon, Silvia Ziliotto, Julia M.W. Gee, Kathryn M. Taylor
Format: Article
Language:English
Published: Open Exploration Publishing Inc. 2022-04-01
Series:Exploration of Targeted Anti-tumor Therapy
Subjects:
Online Access:https://www.explorationpub.com/Journals/etat/Article/100280