Proximity of Cytomegalovirus-Specific CD8+ T Cells to Replicative Senescence in Human Immunodeficiency Virus-Infected Individuals

Proximity of Cytomegalovirus-Specific CD8+ T Cells to Replicative Senescence in Human Immunodeficiency Virus-Infected Individuals

Antiretroviral therapy (ART) effectively extends the life expectancy of human immunodeficiency virus (HIV)-infected individuals; however, age-related morbidities have emerged as major clinical concerns. In this context, coinfection with cytomegalovirus (CMV) accelerates immune senescence and elevate...

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Bibliographic Details
Main Authors: John Joseph Heath, Neva Jennifer Fudge, Maureen Elizabeth Gallant, Michael David Grant
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-02-01
Series:Frontiers in Immunology
Subjects:
cytomegalovirus
human immunodeficiency virus
CD8+ T cell
senescence
telomere length
inflammation
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2018.00201/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2018.00201/full

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